I have created a little chat application that seems to work 100% on Mozilla Firefox, Google Chrome, and Safari, (tried it in Opera, and it seems to work, but the cookies are screwing everything up; this is probably because my install is not being run under an administrator account), but not Internet Explorer.
Chat • Login
http://preview.moltx.name/chat_v2/library.js
Everything works fine, up until you get to the chat room itself. Internet Explorer just sits, and does nothing. Doesn't even have an error. It seems to be able to send data (but not fully; send a message using Internet Explorer, and then check the active users list on another browser), and is completely non responsive to data received.
It's made with JavaScript + PHP.