Excluding Access from your thinking makes that extremely difficult.
Access as a front end to a cloud database (Azure SQL being probably the most obvious) with a PowerApps interface for the simpler tasks but with the main management & higher-level work being done on a desktop, is a perfect solution, as well as being :
- Cheapest by far.
- Easiest by far.
- Quickest by far.
On the other hand, there are people with experience in other expertise who have, and would, do this using various other technologies. It is no exaggeration to point out that the success rates are considerably lower - IE. that many fail ever even to get produced; the time invested is generally increased by a factor of 300% (Access is a famously competent tool for RAD (Rapid Application development)); the costs are obviously much higher than doing it in Access + PowerApps.
Feel free to assume that I am biased in favour of Access. As a long-term Access MVP that could be assumed. Nevertheless, you may also want to consider the reams of content available that says pretty much what I do here. It's not an accident that I agree with so much of what is generally known. You may not know that I have personal experience of working in other languages - including but not limited to c, c++ & even Intel Assembler back in the day. I also loved working in those languages. Nevertheless none could produce product as quickly & effectively as Access can with VBA (Not my favourite language by far but so effective when twinned with Access).
Nor do I lose sight of the unfortunate fact that the reason for your choice may not be entirely in your own hands. There are many IT departments who conflate some internal Access apps with the concept of using Access properly in a fully protected environment. If you need to find a solution where Access isn't included then there are answers. You should understand they will not be comparable in many ways as producing them will be slower & more expensive by a fairly chunky factor, and also that asking in this particular forum (Not site - Bytes.com - but this Access forum) is unlikely to yield the most positive results.
Ultimately, whatever you decide, & I can only provide information for your consideration, I/we wish you the best in your endeavours.