If you mean VB6 and VB.NET there are some common ideas but you move from using ADO to access your data to ADO.NET. ADO.NET is a disconnected architecture, that is requests are made to the server and kept local until updates are sent back to the server. It incorporates a number of new features such as a DataSet (where several tables, related or unrelated can be stored), a dataAdapter that connects you to your data, datatables, datarows and the like.
Look adding a DataSet to a project, dragging tableAdapters onto it and using TypedDataSets to access your data. You will really like it.